As is often the case, there is no one single treatment that is best for all women. Although oral progesterone may be sufficient for some women, Crinone and progesterone in oil do appear to be the most effective at the uterine level. The issue of whether either of these two supplementation forms is superior to the other remains unresolved. Some preliminary research suggests that progesterone in oil is superior at preventing bleeding in pregnancy, but that it may also delay bleeding in some cases where genetically abnormal pregnancies ultimately result in blighted ova. Definitive research is, however, yet to be done.
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