SAFETY DATA SHEET
(dir. 93/112/CEE)
Date of elaboration : 23/12/03
Updating date : 17/10/05
Name of product : PROGESTERONE
Product not regulated by European directive 2000/32/CE, last TPA of directive 67/548/CE
Label : T R : 40*60*63
S : 3/7/9*22*36/37/39*45
Symbols :
F . Easily inflammable X n . Noxious C . Corrosive O . Oxidizer
E . Explosive T . Toxic T+ Very Toxic X i . Irritant |
1. Chemical Product and Company Identification
*- Trade name : PROGESTERONE
*- Supplier : BimSiframGroup
*- Importer : BimSiframGroup - 42, Rue du Fbg Poissonnière - F.75010 PARIS / FRANCE
*- Emergency tel. N° France : 01 45 42 59 59 (Orfila)
*- Use : Pharmaceutical
2. Composition / Information on Ingredients
*- Chemical name: Pregn-4-ene-3,20-dione 2
*- Synonyms : Progesteronum
*- CAS N° : 57-83-0
*- EEC N° : 200-350-6
*- Molecular weight : 314.46
*- Molecular formula : C21H30O2
3. Hazards Identification
Symbol : T - toxique
R 40 : Limited evidence of a carcinogenic effect.
R 60 : May impair fertility.
R 63 : Possible risk of impaired fertility.
4. First-Aid Measures
*- In case of contact with skin: Flush with copious amounts of water for at least 15 minutes.
*- In case of contact with eyes: Assure adequate flushing by separating the eyelids with fingers. Flush with copious amounts of water for at least 15 minutes.
*- In case of inhalation: Remove to fresh air away from exposure site. If breathing is difficult give oxygen. If not breathing give artificial respiration.
*- In case of ingestion: Wash out mouth with water provided person is conscious.
In all above cases call a Physician
Remove and wash contaminated clothing.
5. Fire Fighting Measures
*- Extinguishing media : Water spray - carbon dioxide - Dry chemical powder or appropriate foam.
*- Special fire fighting procedures : Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
6. Accidental Release Measures
*- Evacuate area, and wear same protections than describes in section 7.
*- Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pick up is complete.
*- Avoid any penetration in sewerage system or watercourse. In case of penetration alert the authorities.
7. Handling and Storage
*- Handling : Avoid breathing dust, vapour, mist, or gas. Avoid contact with skin and eyes. Store protected from light. Use only in a chemical fume hood. Avoid all contact.
*- Storage : Protect from light. Keep in a cool, dry place and in a tightly closed container.
8. Exposure Controls / Personal Protection
*- Engineering Controls : Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
*- Eyes : Wear chemical goggles.
*- Skin : Wear appropriate gloves to prevent skin exposure.
*- Clothing : Wear a chemical apron.
*- Respirators : A NIOSH/MSHA approved air purifying dust or mist respirator or European Standard EN 149.
9. Physical and Chemical Properties
*- Appearance : White-Beige
*- Odour : Inodour
*- Specific optical rotation : + 186 ~ +194
*- Decomposition temperature : 128°C ~ 132°C
10. Stability and Reactivity
*- Incompatibilities with strong oxidising agents.
*- Hazardous combustion or decomposition products: carbon monoxide and dioxide.
*- Hazardous polymerisation has not been reported.
11. Toxicological Information
*- Toxicity data: not available.
*- Other data : for complete data see corresponding articles in the RTECS
*- RTECS Nr: CAS# 57-83-0: TW0175000
*- Carcinogenicity : PROGESTERONE, 98% - California : carcinogen; initial date 1/1/88 NTP: Suspect carcinogen OSHA: Possible Select carcinogen See actual entry in RTECS for complete information
12. Ecological Information
Any flow in the sewerage system or watercourse must be avoided.
Data not yet available.
13. Disposal Considerations
*- Product:
In absence of a uniform regulation concerning disposal of chemical products and residues in the EC. They must be considered as special waste. Their disposal is regulated by each member of the EC. We recommend you to contact your local authority, they will inform you about which measures to adopt. Only in case they don't have special measures for this product, you can use this one: dissolve or mix the material with a combustible solvent in a chemical incinerator equipped with an afterburner and scrubber.
*- Packaging : Disposal following the official regulations.
14. Transport information
* - This product is not submitted to transport regulations
15. Regulatory information
*- Label according to EEC - Symbol : T - codes : R: 40*60*63 S: 3/7/9 *22*36/37/39*45
Symbol : Toxic
R 40 : Limited evidence of a carcinogenic effect.
R 60 : May impair fertility.
R 63 : Possible risk of impaired fertility.
S 3/7/9 : Keep container tightly closed in a cool and well-ventilated place.
S 22 : Do not breathe dust.
S 36/37/39 : Wear suitable protective clothing, gloves and eye/face protection.
S 45 : In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible
*- EEC N° (EINECS) : 200-350-6
*- Product not regulated by European directive 2000/32/CE, last TPA of directive 67/548/CE
16. Other information
The above information is based on actual knowledge relatives to the concerned product, on the update date. They are believed to be correct. This sheet is not a guaranty concerning the product properties and shall be used as a guide. Its user has to conformed it self to the whole regulatory texts concerning his activity.
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