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Knowledges of paracetamol:
 

History of paracetamol
Available forms of paracetamol
Mechanism of action of paracetamol
Metabolism of paracetamol
MSDS (Material Safety Data Sheet) for paracetamol
Comparison with NSAIDs
Toxicity of paracetamol
Natural history of paracetamol
Initial treatment for uncomplicated paracetamol overdose
Acetylcysteine and paracetamol
Prognosis for paracetamol
Effects on animals of paracetamol

MSDS for aspirin (in french)

SAFETY DATA SHEET (dir. 93/112/CEE)

D ate of elaboration: 22/08/06 Updating date: 20/02/07
established by : SG Validated by : LM

Name of product : PARACETAMOL

Product not regulated by European directive 2000/32/CE, last TPA of directive 67/548/CE

Label : X n R: 22-36/37/38
S: 26-36

Symbol of danger: X n . Harmful X i . Irritant E . Explosive F . Highly flammable
O . Oxidizing T . Toxic T+ . Very toxic C . Corrosive N. Dangerous for environment

1. Chemical Product and Company Identification

*- Trade name: PARACETAMOL
*- Supplier : BIM SIFRAM GROUP
*- Importeur: BIM SIFRAM GROUP
42 Rue du Faubourg Poissonnière
75010 PARIS
*- Emergency tel. N°: 01 45 42 59 59 (Orfila)
*- Use: Pharmaceutical

2. Composition / Information on Ingredients

N° CAS : 103-90-2 N° EINECS : 203-157-5
Molecular formula : C 8 H 9 NO 2 Molecular weight :  

*- Chemical name : 4-Acetamidophenol
*- Synonyms : Acetaminophen * p-Hydroxyacetanilide * APAP * Paracetamol

3. Hazards Identification

Symbol: X n
R22-36/37/38: Harmful if swallowed. Irritating to eyes, respiratory system and skin.

4. First-Aid Measures

*- In case of inhalation: Remove to fresh air away from exposure site. If breathing is difficult give oxygen. If not breathing give artificial respiration.
*- In case of contact with skin: Flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes.
*- In case of contact with eyes : Assure adequate flushing by separating the eyelids with fingers. Flush with copious amounts of water for at least 15 minutes.
*- In case of ingestion: Wash out mouth with water provided person is conscious.

In all above cases call a Physician

5. Fire Fighting Measures

*- Extinguishing media: Water spray, carbon dioxide, dry chemical powder or appropriate foam.
*- Special fire fighting procedures: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
*- Special risks : Emits toxic fumes under fire conditions.

6. Accidental Release Measures

*- Procedure of personal precaution : Wear respirator, chemical safety goggles, rubber boots, and heavy rubber gloves.
*- Methods for cleaning up: Sweep up, place in a bag and hold for waste disposal (to see heading 13). Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
*- Avoid any penetration in sewerage system or watercourse. In case of penetration alert the authorities.

7. Handling and Storage

*- Handling : Do not breathe dust. Avoid contact with eyes, skin, and clothing. Avoid prolonged or repeated exposure.
*- Storage : Keep tightly closed.

8. Exposure Controls / Personal Protection

*- Mechanical exhaust required.
*- Safety shower and eye bath.
*- Respiratory Protection: Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
*- Hand Protection: Compatible chemical-resistant gloves.
*- Eye Protection: Chemical safety goggles.
*- General hygiene measures: Wash thoroughly after handling.
To wash the clothing contaminated before re-use.

9. Physical and Chemical Properties

*- Appareance: powder
*- Color: white
*- Odour: /
*- pH: 5.5 ~ 6.5
*- Decomposition Temperature: > 180°C
*- Flash point: /
*- Autoignition temperature: 540°C
*- Solubility: 14 g/l in the water
*- Melting point: 168°C ~ 172°C
*- Specific optical rotation: /
*- Limits of exposure: minimum: 15 Vol%

10. Stability and Reactivity

*- Stability: Stable under the conditions of storage mentioned in heading 7.
*- Materials to Avoid: oxidizing agents
*- Conditions to avoid: Light and incompatible products
*- Hazardous Polymerization: Will not occur
*- Decomposition products : Carbon monoxide, carbon dioxide, nitrogen oxides.

11. Toxicological Information

*- Toxicity data :
Acute toxicity:
DL50 - ORAL rat: 1944 mg/kg DL50 - ORAL mouse: 338 mg/kg
DL50 - Intraperitoneal rat: 1205mg/kg DL50 - Intraperitoneal mouse: 367 mg/kg
DL50 - Subcutaneous mouse: 310 mg/kg

Signs and symptoms of exposure:
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

 

Route of exposure:
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.

*- for complete data see corresponding articles in the RTECS: # AE4200000

12. Ecological Information

Any flow in the sewerage system or watercourse must be avoided.
Data not yet available.

13. Disposal Considerations

*- Produit
In absence of a uniform regulation concerning disposal of chemical products and residues in the EC. They must be considered as special waste. Their disposal is regulated by each member of the EC. We recommend you to contact your local authority, they will inform you about which measures to adopt.
Only in case they don't have special measures for this product, you can use this one: dissolve or mix the material with a combustible solvent in a chemical incinerator equipped with an afterburner and scrubber.

*- Packaging:
Disposal following the official regulations.

14. Transport information

*- This product is not submitted to transport regulations

15. Regulatory information

*- Label according to EEC : Symbol  : X n
R22-36/37/38: Harmful if swallowed. Irritating to eyes, respiratory system and skin.

S 26-36: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

16. Other information

The above information is based on actual knowledge relatives to the concerned product, on the updated date. It is believed to be correct. This sheet is not a guaranty concerning the product properties and shall be used as a guide. Its user has to conform itself to the whole regulatory texts concerning its activity.

Note : All Informations given are a summary of different scientific publications.




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