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Knowledges of paracetamol:
 

History of paracetamol
Available forms of paracetamol
Mechanism of action of paracetamol
Metabolism of paracetamol
MSDS (Material Safety Data Sheet) for paracetamol
Comparison with NSAIDs
Toxicity of paracetamol
Natural history of paracetamol
Initial treatment for uncomplicated paracetamol overdose
Acetylcysteine and paracetamol
Prognosis for paracetamol
Effects on animals of paracetamol

Available forms of paracetamol

Panadol, which is marketed in Europe, Africa, Asia, Central America, and Australasia, is the most widely available brand, sold in over 80 countries. In North America, paracetamol is sold in generic form (usually labelled as acetaminophen) or under a number of trade names: for instance Tylenol (McNeil-PPC, Inc), Anacin-3, Tempra, and Datril.

In some formulations paracetamol is combined with the opioid codeine, sometimes referred to as co-codamol (BAN). In the United States and Canada, this is marketed under the name of Tylenol #1/2/3/4 and in the U.S. is only available by prescription, while the lowest strength is over-the-counter in Canada. In the UK and in many other countries, this combination is marketed under the names of Tylex CD and Panadeine. Other names include Captin, Disprol, Dymadon, Fensum, Hedex, Mexalen, Nofedol, Paralen, Pediapirin, Perfalgan, and Solpadeine. Paracetamol is also combined with other opioids such as dihydrocodeine, referred to as co-dydramol (BAN), oxycodone or hydrocodone, marketed in the U.S. as Percocet and Vicodin, respectively. Another very commonly used analgesic combination includes paracetamol in combination with propoxyphene napsylate, sold under the brand name Darvocet. A combination of paracetamol, codeine, and the calmative doxylamine succinate is marketed as Syndol or Mersyndol.

Paracetamol is commonly used in multi-ingredient preparations for migraine headache, typically including butalbital and paracetamol with or without caffeine, and sometimes containing codeine. In the U.S., these anti-migraine products are marketed under the brand name Fioricet.


500 mg Panadol suppositoriesIt is commonly administered in tablet, liquid suspension, suppository, intravenous or intramuscular form. The common adult dose is 500 mg to 1000 mg. The recommended maximum daily dose, for adults, is 4 grams. In recommended doses paracetamol is safe for children and infants as well as for adults.


Note : All Informations given are a summary of different scientific publications.




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