Primarily bacteriostatic, a Tetracycline derivative which is obtained from Streptomyces rimosus.
Hares the same spectrum of activity with Tetracycline, however, other semi-synthetic tetracyclines produce longer effects and can be given in lower and less frequent doses than can oxytetracycline.
It is widely distributed to organs and tissues, but only a small amount to central spinal fluid. It is eliminated unchanged primarily via glomerular filtration and may accumulate with repeated dosing in those with impaired renal function. The drug is apparently not metabolized, but excreted into the GI tract where it may become inactive after chelation with fecal material. |
