SAFETY DATA SHEET
(dir. 93/112/CEE)
Date of elaboration : 18/04/2002
Updating date : 17/10/05
Name of product : Oxytetracycline Hydrochloride
Product not regulated by European directive 2000/32/CE, last TPA of directive 67/548/CE
Label : X n R : 63
S : 22-36/37
Symbols :
F . Easily inflammable X n . Noxious C . Corrosive O . Oxidizer
E . Explosive T . Toxic T+ Very Toxic X i . Irritant |
1. Chemical Product and Company Identification
*- Trade name : OXYTETRACYCLINE BASE
*- Supplier : BimSiframGroup
*- Importer : BimSiframGroup - 42 Rue du Faubourg Poissonnière - F.75010 PARIS / FRANCE
*- Emergency tel. N° France : 01 45 42 59 59 (Orfila)
*- Use : Pharmaceutical
2. Composition / Information on Ingredients
*- Chemical name: 2- Naphthacenecarboxamide, 4-(Dimethylamino)-1, 4, 4a, 5, 5a, 6, 11, 12a-Octahydro-3, 5, 6, 10, 12, 12a-Hexahydroxy-6- méthyl-1, 11-dioxo-(4S-(4-alpha, 4a-alpha, 5-alpha, 5a-alpha, 6-beta, 12a-alpha) ) -dihydrate
*- Synonyms: Adamycin * Dabicycline * 5- Hydroxytetracycline * Lenocycline * Oxitetracyclin
*- CAS N° : 79-57-2
*- EEC N° : 201-212-8
*- Molecular weight: 496,47
*- Molecular formula: C22H24N2O9.2H2O
3. Hazards Identification
Symbol : X n
*- Harmful
*- R 63: Possible risk of harm to the unborn child.
*- Target organ(s): teeth, blood.
4. First-Aid Measures
*- In case of contact with skin: Flush with copious amounts of water for at least 15 minutes.
*- In case of contact with eyes: Assure adequate flushing by separating the eyelids with fingers. Flush with copious amounts of water for at least 15 minutes.
*- In case of inhalation: Remove to fresh air away from exposure site. If breathing is difficult give oxygen. If not breathing give artificial respiration.
*- In case of ingestion: Wash out mouth with water provided person is conscious.
*- Remove and wash contaminated clothing.
In all above cases call a Physician
5. Fire Fighting Measures
*- Extinguishing media: Non combustible. Use extinguishing media appropriate to surrounding fire conditions.
*- Special fire fighting procedures: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
*- Emits toxic fumes under fire conditions.
6. Accidental Release Measures
*- Evacuate area.
*- Wear self-contained breathing apparatus, rubber boots and heavy rubber gloves.
*- Sweep up, place in a bag and hold for waste disposal.
*- Avoid raising dust.
*- Ventilate area and wash spill site after material pick up is complete.
*- Avoid any penetration in sewerage system or watercourse. In case of penetration alert the authorities.
7. Handling and Storage
*- Handling : Do not breath dust.
Do not get in eyes, on skin, on clothing.
Avoid prolonged or repeated exposure
Possible teratogen.
*- Storage : Store in tightly closed containers in a cool dry place.
8. Exposure Controls / Personal Protection
See section 7 :
*- Wear appropriate NIOSH/MSHA approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
*- Mechanical exhaust required
*- Safety shower and eye bath.
*- Wash thoroughly after handling
9. Physical and Chemical Properties
*- Appearance : Yellow crystalline powder
*- pH : 4.5 ~ 7.5
*- Specific optical rotation : 203° ~ -216°
*- Melting point : 182 °C ~ 184 °C
10. Stability and Reactivity
*- Stable under normal pressures and temperatures.
*- Incompatibilities with strong bases.
*- Hazardous combustion or decomposition products: carbon monoxide and dioxide, nitrogen oxides.
*- Hazardous polymerisation will not occur.
11. Toxicological Information
*- Acute effects:
Harmful if swallowed, inhaled or absorbed through skin.
May cause eye irritation.
May cause skin irritation.
Material may be irritating to mucous membranes and upper respiratory tract.
*- Chronic effects:
Overexposure may cause reproductive disorder(s) based on tests with laboratory animals.
Target organ(s): teeth, blood
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
*- Toxicity data: ORL-RAT LD 50: 4800 mg/Kg
IVN-RAT LD 50 : 260 mg/KG
*- Other data : for complete data see corresponding articles in the RTECS
*- RTECS Nr: OI7875000
12. Ecological Information
*- Any flow in the sewerage system or watercourse must be avoided.
Data not yet available.
13. Disposal Considerations
*- Product: In absence of a uniform regulation concerning disposal of chemical products and residues in the EC, they must be considered as special waste. Their disposal is regulated by each member of the EC. We recommend you to contact your local authority; they will inform you about which measures to adopt.
Only in case they don't have special measures for this product, you can use this one: dissolve or mix the material with a combustible solvent in a chemical incinerator equipped with an afterburner and scrubber.
*- Packaging: Disposal following the official regulations.
14. Transport information
*- This product is not submitted to transport regulations
15. Regulatory information
*- Label according to EEC - Symbol : X n - codes : R:63 S: 22-36/37
*- Harmful
*- R 63 : Possible risk of harm to the unborn child.
*- S 22 : Do not breathe dust.
S 36/37 : Wear suitable protective clothing and gloves.
*- EEC N° (EINECS) : 201-212-8
*- Product not regulated by European directive 2000/32/CE, Last TPA of directive 67/548/CE
CAS# 79-57-2 is listed on Canada 's DSL List
CAS# 79-57-2 is listed on the TSCA Inventory.
16. Other information
The above information is based on actual knowledge relatives to the concerned product, on the update date. They are believed to be correct. This sheet is not a guaranty concerning the product properties and shall be used as a guide. Its user has to conformed it self to the whole regulatory texts concerning his activity.
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