SAFETY DATA SHEET
(dir. 93/112/CEE)
Date of elaboration : 18/04/2002
Updating date : 17/10/05
Name of product : Oxytetracycline Hydrochloride
Product not regulated by European directive 2000/32/CE, last TPA of directive 67/548/CE
Label : X n R : 63
S : 45-53-36/37/39
Symbols :
F . Easily inflammable X n . Noxious C . Corrosive O . Oxidizer
E . Explosive T . Toxic T+ Very Toxic X i . Irritant |
1. Chemical Product and Company Identification
*- Trade name : OXYTETRACYCLINE HYDROCHLORIDE
*- Supplier : BimSiframGroup
*- Importer : BimSiframGroup - 42 Rue du Faubourg Poissonnière - F.75010 PARIS / FRANCE
*- Emergency tel. N° France : 01 45 42 59 59 (Orfila)
*- Use : Pharmaceutical
2. Composition / Information on Ingredients
*- Chemical name: Oxytetracycline Hydrochloride
*- Synonyms : Aquacycline * Hydroxytetracycline hydrochloride * Oxlopar * Terramycin hydrochloride
*- CAS N° : 2058-46-0
*- EEC N° : 218-161-2
*- Molecular weight : 496.90
*- Molecular formula : C22H24N2O9HCl
3. Hazards Identification
Symbol : X n
R 63 : Possible risk of harm to the unborn child
4. First-Aid Measures
*- In case of contact with skin: Flush with copious amounts of water for at least 15 minutes.
*- In case of contact with eyes: Assure adequate flushing by separating the eyelids with fingers. Flush with copious amounts of water for at least 15 minutes.
*- In case of inhalation: Remove to fresh air away from exposure site. If breathing is difficult give oxygen. If not breathing give artificial respiration.
*- In case of ingestion: Wash out mouth with water provided person is conscious.
In all above cases call a Physician
Remove and wash contaminated clothing.
5. Fire Fighting Measures
*- Extinguishing media: Water spray - carbon dioxide - Dry chemical powder or appropriate foam.
*- Special fire fighting procedures: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
*- Emits toxic fumes under fire conditions.
6. Accidental Release Measures
*- Evacuate area
*- Wear self-contained breathing apparatus, rubber boots and heavy rubber gloves.
*- Wear disposal coveralls and discard them after use.
*- Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pick up is complete.
*- Avoid any penetration in sewerage system or watercourse. In case of penetration alert the authorities.
7. Handling and Storage
*- Handling : Do not breath dust.
Do not get in eyes, on skin, on clothing.
Avoid prolonged or repeated exposure.
Possible teratogen.
Use only in a chemical fume hood.
*- Storage : Store in tightly closed containers in a cool dry place, protected from light. Store under nitrogen.
*- Wash after handling.
8. Exposure Controls / Personal Protection
See section 7 :
*- Wear appropriate NIOSH/MSHA approved respirator, chemical-resistant gloves, safety goggles, other protective clothing. Mechanical exhaust required.
*- Use only in a ventilated area.
*- Safety shower and eye bath.
*- Wash thoroughly after handling.
*- Wash contaminated clothing before reuse.
9. Physical and Chemical Properties
*- Appearance : Yellow crystalline powder, hydroscopic
*- Specific optical rotation : - 188° ~ - 200°
*- pH : 2.3 ~ 2.9
*- Solubility: Freely soluble in water, sparingly soluble in alcohol
10. Stability and Reactivity
*- Stability : Stable under normal pressures and temperatures
*- Incompatibilities with strong bases
*- Sensitive to air and light
*- Hazardous combustion or decomposition products: carbon monoxide and dioxide, nitrogen oxides, hydrogen chloride gas.
*- Hazardous polymerisation will not occur.
11. Toxicological Information
*- Accute effects : May be harmful if swallowed, inhaled or absorbed through skin.
May cause eye irritation and skin irritation.
Material may be irritating to mucous membranes and upper respiratory tract.
*- Chronic effects : Possible risk of congenital malformation in the fetus.
This product is or contains a component that is not classifiable as to its carcinobenicity based on its IARC, ACGIH, NTP or EPA.
*- Toxicity data: SCU, RAT LD 50 = 800 mg/Kg ; IVN-RAT LD 50 = 302 mg / Kg
*- Other data : for complete data see corresponding articles in the RTECS
*- RTECS Nr: # OI8225000
2-Naphthacenecarboxamide
4- ( Dimethylamino ) - 1, 4, 4A, 5, 5A, 6, 11, 12A-Octahydro-3, 5, 6, 10, 12A-Hexahydroxy-6-méthyl-1, 11-Dioxo-, Monohydrochloride
12. Ecological Information
Any flow in the sewerage system or watercourse must be avoided.
Data not yet available.
13. Disposal Considerations
*- Product: In absence of a uniform regulation concerning disposal of chemical products and residues in the EC. They must be considered as special waste. Their disposal is regulated by each member of the EC. We recommend you to contact your local authority, they will inform you about which measures to adopt.
Only in case they don't have special measures for this product, you can use this one: dissolve or mix the material with a combustible solvent in a chemical incinerator equipped with an afterburner and scrubber.
*- Packaging: Disposal following the official regulations.
14. Transport information
* - This product is not submitted to transport regulations
15. Regulatory information
*- Label according to EEC - Symbol : X n - codes : R: 63 S: 45-53-36/37/39
Symbol : X n
R 63 : Possible risk of harm to the unborn child
S 45 : In case of accident or if you feel unwell, seek medical advice immediately ( show the label where possible )
S 53 : Avoid exposure - Obtain special instructions before use.
S 36/37/39 : Wear suitable protective clothing, gloves and eye/face protection.
*- EEC N° (EINECS) : 218-161-2
*- Product not regulated by European directive 2000/32/CE, Last TPA of directive 67/548/CE
*- California Prop. 65 reproductive hazard.
16. Other information
The above information is based on actual knowledge relatives to the concerned product, on the update date. They are believed to be correct. This sheet is not a guaranty concerning the product properties and shall be used as a guide. Its user has to conformed it self to the whole regulatory texts concerning his activity. |
