There is not much known about the pharmacokinetics of hesperidin in humans. It is unclear if hesperidin itself is absorbed from the intestine intact as a glycoside. The aglycone hesperetin is detected in the serum following ingestion and may be formed prior to or following absorption. Hesperetin may undergo glucuronidation in the wall of the intestine, as well as in the liver. Hesperetin is detected in the urine within three hours after ingestion of hesperidin. Urinary excretion appears to be the major route of excretion of the aglycone. Not much more is known about the metabolism of hesperidin. |
